Nicotine attenuates iNOS and nNOS expression in a contusion model of spinal cord injury
نویسندگان
چکیده
منابع مشابه
effect of estrogen therapy on tnf-α and inos gene expression in spinal cord injury model
spinal cord injury (sci) is a crucial complication that results in neurons degeneration. the sci lead to triggering of secondary complications such as inflammation that in turn has a key role in neurodegeneration development. the previous studies showed that tnf-α and inos genes expression increased significantly after sci. as a consequence, these genes overexpression intensify the inflammation...
متن کاملA contusion model of severe spinal cord injury in rats.
The translational potential of novel treatments should be investigated in severe spinal cord injury (SCI) contusion models. A detailed methodology is described to obtain a consistent model of severe SCI. Use of a stereotactic frame and computer controlled impactor allows for creation of reproducible injury. Hypothermia and urinary tract infection pose significant challenges in the post-operativ...
متن کاملeffect of progesterone therapy on tnf-α and inos gene expression in spinal cord injury model
spinal cord injury (sci) as a destructive crash result in neurons degeneration. the sci lead to the onset of biochemical and molecular cascades such as inflammation that in turn has a key role in neurodegeneration development. the previous studies demonstrated the role of tnf-α and inos genes in intensifying the process after sci. as a consequence, these genes overexpression intensify the infla...
متن کاملThermostabilized chondroitinase ABC Promotes Neuroprotection after Contusion Spinal Cord Injury
Background: Chondroitinase ABC (cABC), due to its loosening impact on the extracellular matrix scaffold, has been used to enhance regeneration of injured axonal tracts after spinal cord injury (SCI). However, cABC thermal instability at physiological temperature has limited its clinical application. The disaccharide trehalose has been shown to increase the stability of cABC in body temperature....
متن کاملAberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model
Long noncoding RNAs (LncRNAs) play a crucial role in cell growth, development, and various diseases related to the central nervous system. However, LncRNA differential expression profiles in spinal cord injury are yet to be reported. In this study, we profiled the expression pattern of LncRNAs using a microarray method in a contusion spinal cord injury (SCI) mouse model. Compared with a spinal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a786-c